VEGF
Vascular Endothelial Growth Factor (VEGF-A)
The primary driver of angiogenesis (new blood vessel formation). Critical for wound healing and tissue repair. Anti-VEGF therapies are used for cancer and macular degeneration.
Mechanism of Action
VEGF binds to VEGFR1 and VEGFR2 receptors on endothelial cells, stimulating proliferation, migration, and new blood vessel formation. It also increases vascular permeability.
Health Claims & Evidence
Promotes angiogenesis and tissue vascularization
Supports wound healing via blood vessel formation
Potential ischemia treatment via therapeutic angiogenesis
Short-Term Effects
Angiogenesis promotion, wound healing acceleration.
Long-Term Effects
Research use primarily.
Side Effects
Edema, potential tumor promotion, retinal neovascularization.
Contraindications
Contraindicated with active cancer or retinal neovascularization.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
VEGF and angiogenesis
Ferrara et al. · Biochemical and Biophysical Research Communications · 1989
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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