Enkephalin
Enkephalin (Met-Enkephalin / Leu-Enkephalin)
Short endogenous opioid pentapeptides that modulate pain, mood, and immune function. Met-enkephalin (MENK) has shown promise as an immune modulator and anti-cancer agent.
Mechanism of Action
Enkephalins bind to delta and mu opioid receptors, modulating pain transmission, mood, and immune function. Met-enkephalin specifically activates opioid growth factor receptors (OGFr) with anti-proliferative effects.
Health Claims & Evidence
Pain modulation via opioid receptors
Immune modulation and anti-cancer effects (MENK)
Mood regulation
Short-Term Effects
Pain modulation, mood effects.
Long-Term Effects
Research use primarily.
Side Effects
Tolerance with repeated use. Less respiratory depression than beta-endorphin.
Contraindications
Opioid receptor activity — use with caution.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Met-enkephalin and immune function
Zagon et al. · Brain Research · 2003
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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