NAP (NAPVSIPQ)
NAP Peptide (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln)
An 8-amino acid neuroprotective peptide derived from the activity-dependent neuroprotective protein (ADNP). Shows remarkable neuroprotective effects at femtomolar concentrations.
Mechanism of Action
NAP interacts with tubulin and microtubule-associated proteins, stabilizing neuronal cytoskeleton integrity. It activates neuroprotective pathways, reduces tau hyperphosphorylation, and protects against amyloid-beta toxicity.
Health Claims & Evidence
Potent neuroprotection at extremely low doses
Reduces Alzheimer's pathology markers
Potential benefit in autism spectrum disorder
Short-Term Effects
Subtle cognitive improvements, improved focus and memory.
Long-Term Effects
Potential neuroprotection and cognitive preservation with long-term use.
Side Effects
Extremely well-tolerated at therapeutic doses.
Contraindications
Limited human data. Use with caution without medical supervision.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
NAP neuroprotection and Alzheimer's disease
Gozes et al. · Journal of Molecular Neuroscience · 2005
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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