Spexin
Spexin (SPX)
A recently discovered neuropeptide related to galanin. Reduces food intake, body weight, and anxiety. Levels are reduced in obesity.
Mechanism of Action
Spexin binds to galanin receptor 2 and 3 (GALR2/3), reducing appetite and food intake. It also has anxiolytic effects and modulates reproductive function.
Health Claims & Evidence
Reduces appetite and body weight
Anxiolytic effects
Reduced in obesity — restoration may help
Short-Term Effects
Appetite suppression, potential anxiolytic effects.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Spexin and body weight regulation
Walewski et al. · Obesity · 2014
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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