PYY
Peptide YY (PYY 3-36)
A gut hormone released after meals that reduces appetite by acting on hypothalamic NPY receptors. PYY 3-36 is the active form that crosses the blood-brain barrier.
Mechanism of Action
PYY 3-36 binds to Y2 receptors in the hypothalamus, inhibiting NPY/AgRP neurons and reducing appetite. It also slows gastric emptying and reduces GI motility.
Health Claims & Evidence
Reduces appetite and food intake
Promotes satiety after meals
Potential obesity treatment
Short-Term Effects
Reduced appetite and food intake within 30–60 minutes.
Long-Term Effects
Potential for sustained appetite reduction with regular use.
Side Effects
Nausea (dose-dependent), headache.
Contraindications
Use with caution in eating disorders.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
PYY 3-36 reduces food intake in humans
Batterham et al. · Nature · 2002
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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