IGF-1 LR3
Insulin-like Growth Factor-1 Long R3
A long-acting analogue of IGF-1 with a significantly extended half-life. Highly anabolic, promoting muscle cell proliferation, differentiation, and satellite cell activation.
Mechanism of Action
IGF-1 LR3 binds to IGF-1 receptors throughout the body, stimulating protein synthesis, glucose uptake, and satellite cell activation in muscle tissue. The LR3 modification reduces binding to IGF-binding proteins, extending its half-life from minutes to approximately 20–30 hours.
Health Claims & Evidence
Potent muscle growth and hyperplasia
Accelerates recovery from training
Supports fat loss via metabolic effects
Short-Term Effects
Rapid muscle fullness, improved recovery, potential hypoglycemia if not managed properly.
Long-Term Effects
Significant muscle hypertrophy and hyperplasia with proper cycling. Risk of insulin resistance with prolonged use.
Side Effects
Hypoglycemia, jaw and organ growth with chronic use, potential for tumor promotion, insulin resistance.
Contraindications
Contraindicated with active cancer. Use with extreme caution in diabetics. Not recommended for beginners.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
IGF-1 and muscle satellite cell activation
Adams et al. · Exercise and Sport Sciences Reviews · 2002
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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