ACTH
Adrenocorticotropic Hormone (ACTH)
The pituitary hormone that stimulates cortisol production from the adrenal cortex. Used diagnostically for adrenal insufficiency and therapeutically for infantile spasms.
Mechanism of Action
ACTH binds to MC2R receptors on adrenal cortex cells, stimulating cortisol synthesis. It also has melanocortin effects via MC1R, MC3R, and MC4R.
Health Claims & Evidence
Stimulates cortisol production
Diagnostic tool for adrenal insufficiency
Treatment for infantile spasms
Short-Term Effects
Cortisol elevation within 30–60 minutes.
Long-Term Effects
Clinical use only.
Side Effects
Cortisol-related effects, hypertension, glucose elevation.
Contraindications
Active infections, psychosis.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
ACTH and adrenal function
Orth et al. · New England Journal of Medicine · 1992
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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