Humanin
Humanin (HN)
A mitochondria-derived peptide with potent neuroprotective, cardioprotective, and anti-aging properties. Levels decline with age and are associated with longevity in centenarians.
Mechanism of Action
Humanin binds to multiple receptors including FPRL1 and gp130, activating STAT3 and AMPK pathways. It inhibits neuronal apoptosis, reduces amyloid-beta toxicity, improves insulin sensitivity, and protects against ischemic damage.
Health Claims & Evidence
Neuroprotection against Alzheimer's pathology
Cardioprotective effects
Improves insulin sensitivity
Longevity association
Short-Term Effects
Improved energy, potential cognitive benefits, enhanced metabolic function.
Long-Term Effects
Potential neuroprotection and longevity benefits with sustained use.
Side Effects
Limited human data. Generally well-tolerated in early studies.
Contraindications
Limited human safety data. Use with caution.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Humanin and Alzheimer's disease protection
Hashimoto et al. · Nature · 2001
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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