Ghrelin
Ghrelin (Appetite-Stimulating Hormone)
The 'hunger hormone' — a gut peptide that stimulates appetite, GH release, and has cardioprotective properties. Used in research for cachexia and GH deficiency.
Mechanism of Action
Ghrelin binds to GHS-R1a receptors in the hypothalamus and pituitary, stimulating appetite and GH release. It also has cardioprotective effects via direct cardiac receptor binding.
Health Claims & Evidence
Potently stimulates appetite and food intake
Stimulates GH release
Cardioprotective effects
Short-Term Effects
Rapid appetite stimulation, GH pulse.
Long-Term Effects
Research use primarily.
Side Effects
Significant appetite stimulation, potential insulin resistance.
Contraindications
Avoid in obesity without medical supervision.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima et al. · Nature · 1999
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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