Cetrorelix
Cetrorelix Acetate (Cetrotide)
A GnRH antagonist that immediately and competitively blocks GnRH receptors, rapidly suppressing LH and FSH without the initial hormone flare seen with GnRH agonists. Used in assisted reproductive technology.
Mechanism of Action
Cetrorelix competitively binds GnRH receptors in the pituitary, immediately blocking LH and FSH release. Unlike GnRH agonists, it produces no initial stimulation, making it ideal for preventing premature LH surges during ovarian stimulation in IVF protocols.
Health Claims & Evidence
Prevents premature LH surge during IVF
Immediate and reversible LH/FSH suppression
Reduces risk of ovarian hyperstimulation syndrome
Short-Term Effects
Rapid LH suppression within 1–2 hours of administration.
Long-Term Effects
Fully reversible upon discontinuation; no long-term hormonal effects.
Side Effects
Injection site reactions, nausea, headache. Rare hypersensitivity reactions.
Contraindications
Pregnancy, severe renal impairment, hypersensitivity to GnRH or mannitol.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Cetrorelix in IVF: a randomized trial
Olivennes et al. · Human Reproduction · 1998
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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