AIB Peptide
Alpha-Aminoisobutyric Acid Peptide (Aib-containing peptides)
Peptides containing alpha-aminoisobutyric acid (Aib), a non-proteinogenic amino acid that induces helical conformations and resistance to proteolysis. Aib-containing peptides are being developed as mitochondria-targeting therapeutics and muscle repair agents.
Mechanism of Action
Aib substitutions force peptide backbones into stable alpha-helical conformations, improving receptor binding affinity and protease resistance. Mitochondria-targeting Aib peptides (like SS-31 analogs) accumulate in the inner mitochondrial membrane, reducing ROS production and improving ATP synthesis.
Health Claims & Evidence
Improves mitochondrial function and reduces oxidative stress
Accelerates muscle recovery from exercise-induced damage
Neuroprotective in ischemia-reperfusion models
Short-Term Effects
Unknown in humans.
Long-Term Effects
Unknown in humans. Animal data suggests mitochondrial protection.
Side Effects
Unknown in humans.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Mitochondria-targeted peptides and cardiac function
Szeto et al. · Journal of Molecular and Cellular Cardiology · 2014
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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