PTH(1-34)
Parathyroid Hormone Fragment 1-34 (Teriparatide)
The biologically active N-terminal fragment of parathyroid hormone, teriparatide (Forteo) is the only FDA-approved anabolic agent for osteoporosis. It stimulates new bone formation rather than merely preventing bone loss.
Mechanism of Action
Intermittent PTH(1-34) administration activates PTH1R receptors on osteoblasts, stimulating bone formation through Wnt signaling and IGF-1 upregulation. Unlike continuous PTH (which is catabolic), pulsatile dosing produces a net anabolic effect, increasing bone mineral density and reducing fracture risk.
Health Claims & Evidence
Increases bone mineral density in osteoporosis
Reduces vertebral and non-vertebral fracture risk
Accelerates fracture healing
Short-Term Effects
Increased bone formation markers within 1–3 months.
Long-Term Effects
Significant BMD increase over 18–24 months; benefits persist after discontinuation if followed by antiresorptive therapy.
Side Effects
Nausea, leg cramps, dizziness, hypercalcemia. Black box warning for osteosarcoma risk (animal data).
Contraindications
Prior radiation therapy to skeleton, Paget's disease, unexplained alkaline phosphatase elevation, pediatric patients, pregnancy.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Teriparatide and vertebral fracture risk
Neer et al. · New England Journal of Medicine · 2001
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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