Musclin
Musclin (Osteocrin)
A muscle-derived peptide that enhances exercise capacity, promotes cardiac remodeling, and modulates natriuretic peptide signaling.
Mechanism of Action
Musclin competes with BNP for NPR-C clearance receptors, increasing circulating BNP levels and cGMP signaling. It also promotes mitochondrial biogenesis in muscle and cardiac tissue.
Health Claims & Evidence
Enhances exercise capacity and endurance
Promotes cardiac remodeling
Modulates natriuretic peptide signaling
Short-Term Effects
Potential exercise capacity improvement.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Musclin and exercise capacity
Subbotina et al. · Science · 2015
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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