Preptin
Preptin (IGF-II E-domain Peptide)
A peptide derived from the E-domain of IGF-II that is co-secreted with insulin. Has anabolic effects on bone and modulates insulin secretion.
Mechanism of Action
Preptin binds to receptors on osteoblasts, stimulating bone formation. It also amplifies glucose-stimulated insulin secretion from pancreatic beta cells.
Health Claims & Evidence
Anabolic effects on bone formation
Amplifies insulin secretion
Potential osteoporosis treatment
Short-Term Effects
Bone formation stimulation, insulin secretion amplification.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Preptin and bone metabolism
Cornish et al. · Proceedings of the National Academy of Sciences · 2007
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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