PACAP
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
A multifunctional neuropeptide with potent neuroprotective, neurotrophic, and anti-inflammatory properties. Implicated in PTSD and migraine.
Mechanism of Action
PACAP binds to PAC1, VPAC1, and VPAC2 receptors, activating cAMP pathways. It promotes neuronal survival, reduces neuroinflammation, modulates stress responses, and has vasodilatory effects.
Health Claims & Evidence
Neuroprotective and neurotrophic effects
Modulates PTSD-related stress responses
Potential migraine treatment
Short-Term Effects
Neuroprotection, vasodilation, potential migraine induction at high doses.
Long-Term Effects
Research use primarily.
Side Effects
Migraine-like headache at high doses, flushing.
Contraindications
Use with caution in migraine sufferers.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
PACAP and neuroprotection
Vaudry et al. · Pharmacological Reviews · 2009
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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