CCK
Cholecystokinin (CCK)
A gut hormone and neuropeptide that signals satiety, stimulates digestion, and modulates anxiety. Plays a key role in the gut-brain axis.
Mechanism of Action
CCK is released from intestinal I-cells in response to fat and protein. It binds to CCK-A receptors in the gut (stimulating digestion) and CCK-B receptors in the brain (producing satiety and anxiolytic effects).
Health Claims & Evidence
Reduces appetite and promotes satiety
Stimulates digestive enzyme secretion
Anxiolytic effects via CCK-B receptors
Short-Term Effects
Rapid satiety, digestive stimulation.
Long-Term Effects
Research use primarily.
Side Effects
Nausea, abdominal cramping at higher doses.
Contraindications
Gallbladder disease (stimulates gallbladder contraction).
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Cholecystokinin and satiety
Gibbs et al. · Journal of Comparative and Physiological Psychology · 1973
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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