BNP
B-type Natriuretic Peptide (BNP)
A cardiac hormone produced by the ventricles in response to increased wall stress. Used diagnostically for heart failure and has vasodilatory and diuretic properties.
Mechanism of Action
BNP binds to natriuretic peptide receptors, activating cGMP pathways that cause vasodilation, natriuresis (sodium excretion), and diuresis. It reduces preload and afterload on the heart.
Health Claims & Evidence
Reduces blood pressure and cardiac preload
Promotes sodium and water excretion
Diagnostic marker for heart failure severity
Short-Term Effects
Rapid blood pressure reduction, diuresis, reduced cardiac symptoms.
Long-Term Effects
Used acutely; not for chronic self-administration.
Side Effects
Hypotension, renal impairment at high doses.
Contraindications
Contraindicated with cardiogenic shock or systolic BP <90 mmHg.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Nesiritide in acute decompensated heart failure
Publication Committee for VMAC. · JAMA · 2002
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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