MK-677
Ibutamoren (MK-677)
A non-peptide oral GH secretagogue that mimics ghrelin. Unique in that it is orally bioavailable, making it one of the most convenient GH-boosting compounds available.
Mechanism of Action
MK-677 binds to ghrelin receptors and stimulates sustained GH and IGF-1 elevation. Unlike injectable GHRPs, it provides a prolonged increase in GH levels rather than a sharp pulse, and its oral bioavailability makes it highly accessible.
Health Claims & Evidence
Significantly increases GH and IGF-1 levels
Improves sleep quality and REM sleep
Supports muscle mass and bone density
Improves skin and hair quality
Short-Term Effects
Improved sleep depth within days, increased appetite, mild water retention.
Long-Term Effects
Sustained IGF-1 elevation, improved body composition, potential bone density improvements.
Side Effects
Significant appetite increase, water retention, potential insulin resistance, increased fasting glucose, lethargy at higher doses.
Contraindications
Use with caution in diabetics or pre-diabetics. Monitor fasting glucose. Avoid with active malignancies.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
MK-677 increases GH and IGF-1 in healthy elderly subjects
Chapman et al. · Journal of Clinical Endocrinology & Metabolism · 1996
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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