Cortistatin
Cortistatin (CST)
A neuropeptide structurally related to somatostatin that promotes slow-wave sleep, reduces locomotor activity, and has potent anti-inflammatory properties.
Mechanism of Action
Cortistatin binds to somatostatin receptors (SSTR1-5) and the MrgX2 receptor. It promotes slow-wave sleep, reduces cortical activity, and has potent anti-inflammatory effects via immune cell modulation.
Health Claims & Evidence
Promotes slow-wave sleep
Potent anti-inflammatory effects
Neuroprotective effects
Short-Term Effects
Slow-wave sleep promotion, anti-inflammatory effects.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data. Potential GH suppression (somatostatin receptor binding).
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Cortistatin and sleep regulation
de Lecea et al. · Nature · 1996
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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