Calcitonin
Calcitonin (Salmon Calcitonin)
A thyroid hormone that regulates calcium and bone metabolism. Salmon calcitonin (FDA-approved) is used for osteoporosis and Paget's disease.
Mechanism of Action
Calcitonin binds to calcitonin receptors on osteoclasts, inhibiting bone resorption and reducing serum calcium. It also has direct analgesic effects on bone pain via central opioid pathways.
Health Claims & Evidence
Reduces bone resorption and treats osteoporosis
Reduces bone pain
Treats Paget's disease of bone
Short-Term Effects
Rapid bone pain relief, calcium lowering.
Long-Term Effects
Sustained bone density preservation with long-term use.
Side Effects
Nasal irritation (intranasal), nausea (injectable), potential increased cancer risk with long-term use.
Contraindications
Potential increased cancer risk with long-term use — monitor.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Calcitonin in osteoporosis treatment
Chesnut et al. · American Journal of Medicine · 2000
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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