Leptin
Leptin (Satiety Hormone)
The primary satiety hormone produced by adipose tissue. Signals energy sufficiency to the hypothalamus, reducing appetite and increasing energy expenditure.
Mechanism of Action
Leptin binds to LepR receptors in the hypothalamus, activating JAK2-STAT3 pathways that suppress appetite (via NPY/AgRP inhibition) and increase energy expenditure. Leptin resistance is a key feature of obesity.
Health Claims & Evidence
Reduces appetite and promotes satiety
Increases energy expenditure
Treatment for leptin deficiency
Short-Term Effects
Appetite reduction in leptin-deficient individuals. Minimal effect in leptin-resistant obesity.
Long-Term Effects
Sustained weight loss in leptin deficiency. Limited efficacy in common obesity.
Side Effects
Injection site reactions, potential antibody formation.
Contraindications
Not effective for common obesity due to leptin resistance.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Leptin and the regulation of body weight
Friedman et al. · Nature · 1998
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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