PDGF
Platelet-Derived Growth Factor (PDGF)
A growth factor released from platelets that promotes wound healing, angiogenesis, and tissue repair. Used in PRP (platelet-rich plasma) therapy.
Mechanism of Action
PDGF binds to PDGFR receptors, activating MAPK and PI3K pathways. It promotes fibroblast and smooth muscle cell proliferation, angiogenesis, and wound healing.
Health Claims & Evidence
Promotes wound healing and tissue repair
Supports bone and tendon repair
Promotes angiogenesis
Short-Term Effects
Accelerated wound healing, angiogenesis promotion.
Long-Term Effects
Sustained wound healing with continued use.
Side Effects
Potential increased cancer risk with repeated use (black box warning for Regranex).
Contraindications
Black box warning: increased cancer risk with 3+ tubes of Regranex.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
PDGF and wound healing
Pierce et al. · Journal of Cell Biology · 1988
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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