Kisspeptin-10
Kisspeptin-10 (KP-10)
A fragment of the kisspeptin neuropeptide that potently stimulates LH and testosterone release. Used for hormonal optimization, fertility support, and libido enhancement.
Mechanism of Action
Kisspeptin-10 binds to KISS1R receptors in the hypothalamus, triggering a strong pulse of GnRH release, which stimulates LH and FSH secretion from the pituitary, leading to increased testosterone production.
Health Claims & Evidence
Potently stimulates LH and testosterone release
Supports fertility and reproductive function
Enhances libido via testosterone elevation
Short-Term Effects
Rapid LH and testosterone pulse within 30–60 minutes of injection.
Long-Term Effects
Potential for sustained testosterone optimization with pulsatile cycling.
Side Effects
Generally well-tolerated. Mild flushing. Receptor desensitization with continuous use.
Contraindications
Use with caution in hormone-sensitive conditions.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Kisspeptin-10 stimulates LH secretion in healthy men
Dhillo et al. · Journal of Clinical Endocrinology & Metabolism · 2005
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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