CNP
C-Type Natriuretic Peptide (CNP)
A natriuretic peptide produced in the vasculature and bone. Regulates bone growth (especially in achondroplasia) and has vasodilatory properties.
Mechanism of Action
CNP binds to NPR-B receptors in chondrocytes and vascular smooth muscle. In bone, it promotes endochondral ossification and long bone growth. In vasculature, it produces vasodilation.
Health Claims & Evidence
Promotes bone growth in achondroplasia
Vasodilatory and cardioprotective effects
Regulates endochondral bone formation
Short-Term Effects
Increased linear growth in achondroplasia.
Long-Term Effects
Sustained growth improvement with continued use.
Side Effects
Injection site reactions, decreased blood pressure.
Contraindications
Use with caution in hypotension.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Vosoritide for achondroplasia
Savarirayan et al. · New England Journal of Medicine · 2020
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on CNP and related peptides, and prepare an educational research summary.
Explore Research