Orexin-A
Orexin-A (Hypocretin-1)
A hypothalamic neuropeptide that promotes wakefulness and regulates appetite. Deficiency causes narcolepsy. Orexin receptor agonists are being developed for narcolepsy treatment.
Mechanism of Action
Orexin-A binds to OX1R and OX2R receptors, promoting wakefulness, arousal, and appetite. It activates norepinephrine, serotonin, and histamine systems. Orexin neuron loss causes narcolepsy with cataplexy.
Health Claims & Evidence
Promotes wakefulness and reduces excessive daytime sleepiness
Potential narcolepsy treatment
Modulates appetite and energy balance
Short-Term Effects
Increased wakefulness, improved alertness, potential appetite stimulation.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data. Potential for excessive wakefulness.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Orexin-A and narcolepsy
Chemelli et al. · Cell · 1999
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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