Neurotensin
Neurotensin (NT)
A neuropeptide that modulates dopamine signaling, pain, and GI function. Has antipsychotic-like properties and is being studied for schizophrenia and pain management.
Mechanism of Action
Neurotensin binds to NTS1, NTS2, and NTS3 receptors. NTS1 activation modulates dopamine neurotransmission (antipsychotic effects), produces analgesia, and regulates body temperature.
Health Claims & Evidence
Antipsychotic-like effects via dopamine modulation
Analgesic effects
Regulates body temperature
Short-Term Effects
Dopamine modulation, analgesia, hypothermia.
Long-Term Effects
Research use primarily.
Side Effects
Hypothermia, sedation at high doses.
Contraindications
Research use only.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Neurotensin and antipsychotic effects
Binder et al. · Neuroscience & Biobehavioral Reviews · 2001
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Neurotensin and related peptides, and prepare an educational research summary.
Explore Research