Substance P
Substance P (SP)
An 11-amino acid neuropeptide involved in pain transmission, inflammation, and wound healing. Has complex roles in both promoting and modulating pain and inflammatory responses.
Mechanism of Action
Substance P binds to NK1 receptors, activating pain and inflammatory pathways. It promotes vasodilation, increases vascular permeability, and stimulates immune cell recruitment. At wound sites, it promotes healing via stem cell recruitment.
Health Claims & Evidence
Promotes wound healing via stem cell recruitment
Modulates pain and inflammatory responses
Supports tissue repair
Short-Term Effects
Local vasodilation, immune cell recruitment, wound healing acceleration.
Long-Term Effects
Research use primarily.
Side Effects
Pain and inflammation with systemic administration. Local use is better tolerated.
Contraindications
Systemic administration not recommended for self-use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Substance P and wound healing
Kant et al. · Wound Repair and Regeneration · 2011
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Substance P and related peptides, and prepare an educational research summary.
Explore Research