LL-37 Fragment
LL-37 Active Fragment (KR-12)
The minimal antimicrobial fragment of LL-37 with reduced toxicity. KR-12 retains antimicrobial activity with improved tolerability.
Mechanism of Action
KR-12 (residues 18-29 of LL-37) retains the core antimicrobial activity of LL-37 with reduced hemolytic toxicity. It disrupts bacterial membranes and promotes wound healing.
Health Claims & Evidence
Antimicrobial activity with reduced toxicity vs full LL-37
Promotes wound healing
Anti-biofilm activity
Short-Term Effects
Reduced local infection, improved wound healing.
Long-Term Effects
Potential for sustained antimicrobial protection.
Side Effects
Better tolerated than full LL-37. Mild local irritation.
Contraindications
Topical use primarily.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
KR-12 minimal antimicrobial peptide from LL-37
Wang et al. · Journal of Biological Chemistry · 2008
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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