TRH
Thyrotropin-Releasing Hormone (TRH)
A tripeptide hypothalamic hormone that stimulates TSH and prolactin release. Has direct neuroprotective and antidepressant effects independent of thyroid function.
Mechanism of Action
TRH binds to TRH receptors in the pituitary (stimulating TSH and prolactin) and in the brain (producing direct neuroprotective and antidepressant effects). It modulates dopamine and serotonin systems.
Health Claims & Evidence
Stimulates thyroid hormone production
Direct antidepressant effects
Neuroprotective in spinal cord injury
Short-Term Effects
Rapid TSH elevation, potential mood improvement.
Long-Term Effects
Potential neuroprotective benefits with repeated use.
Side Effects
Nausea, flushing, urge to urinate, mild hypertension.
Contraindications
Avoid with hyperthyroidism. Use with caution in cardiovascular disease.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
TRH and neuroprotection in spinal cord injury
Faden et al. · New England Journal of Medicine · 1981
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on TRH and related peptides, and prepare an educational research summary.
Explore Research