ACE2 Peptide Fragment
Angiotensin-Converting Enzyme 2 Peptide (DIZE)
Diminazene aceturate (DIZE) and related ACE2-activating peptide fragments that upregulate ACE2 activity, shifting the renin-angiotensin system toward the protective ACE2/Ang-(1-7)/MAS axis to reduce hypertension, cardiac fibrosis, and lung injury.
Mechanism of Action
ACE2 converts angiotensin II (vasoconstrictive, pro-fibrotic) to angiotensin-(1-7) (vasodilatory, anti-fibrotic). ACE2-activating compounds shift this balance, reducing blood pressure, cardiac remodeling, and pulmonary inflammation. The MAS receptor mediates the protective effects of Ang-(1-7).
Health Claims & Evidence
Reduces hypertension via ACE2 upregulation
Reduces cardiac fibrosis and remodeling
Protects against acute lung injury
Short-Term Effects
Unknown in humans.
Long-Term Effects
Unknown in humans. Animal data suggests cardiovascular protection.
Side Effects
Unknown in humans.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
ACE2 and the renin-angiotensin system
Ferrario et al. · Hypertension · 2005
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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