Melanotan II
Melanotan II (MT-II)
A synthetic analogue of alpha-MSH that stimulates melanin production, producing a tan without UV exposure. Also has potent libido-enhancing and appetite-suppressing effects.
Mechanism of Action
Melanotan II activates melanocortin receptors (MC1R–MC4R). MC1R activation stimulates melanin production in skin cells. MC3R and MC4R activation produces sexual arousal and appetite suppression.
Health Claims & Evidence
Stimulates melanin production and skin tanning
Increases libido and sexual function
Suppresses appetite
Short-Term Effects
Nausea (especially initially), facial flushing, spontaneous erections in males, increased libido.
Long-Term Effects
Sustained tan, potential darkening of existing moles — requires monitoring.
Side Effects
Nausea, flushing, spontaneous erections, darkening of moles, blood pressure changes.
Contraindications
Avoid with history of melanoma or dysplastic nevi. Monitor skin changes carefully.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Melanotan II and melanocortin receptor activation
Dorr et al. · Journal of Clinical Endocrinology & Metabolism · 1996
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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