CRH
Corticotropin-Releasing Hormone (CRH)
The primary hypothalamic hormone that initiates the stress response by stimulating ACTH and cortisol release. Also has direct effects on behavior and immune function.
Mechanism of Action
CRH binds to CRH-R1 and CRH-R2 receptors. CRH-R1 activation in the pituitary stimulates ACTH release. CRH-R2 activation has anxiolytic and anti-stress effects. It also modulates immune function.
Health Claims & Evidence
Initiates stress response via HPA axis
Modulates anxiety and stress behavior
Immune modulation
Short-Term Effects
ACTH and cortisol elevation, stress response activation.
Long-Term Effects
Research use primarily.
Side Effects
Anxiety, cardiovascular activation, cortisol elevation.
Contraindications
Not for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
CRH and the stress response
Vale et al. · Science · 1981
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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