Urocortin
Urocortin 1/2/3 (UCN)
A family of CRH-related peptides with cardioprotective, anti-inflammatory, and stress-modulating properties. Urocortin 2 and 3 are being studied for heart failure treatment.
Mechanism of Action
Urocortins bind to CRH-R1 and CRH-R2 receptors. CRH-R2 activation (Urocortin 2/3) produces cardioprotection, vasodilation, and anti-inflammatory effects without the anxiogenic effects of CRH-R1 activation.
Health Claims & Evidence
Cardioprotective and positive inotropic effects
Anti-inflammatory effects
Reduces stress-induced cardiac damage
Short-Term Effects
Improved cardiac function, vasodilation.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Urocortin and cardiac protection
Brar et al. · Circulation · 2004
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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