Sarcolipin
Sarcolipin (SLN) Peptide
A 31-amino acid transmembrane peptide that regulates the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump in muscle, uncoupling calcium transport from ATP hydrolysis to generate heat. Sarcolipin is a key regulator of non-shivering thermogenesis.
Mechanism of Action
Sarcolipin binds SERCA and causes futile calcium cycling — ATP is hydrolyzed but calcium is not efficiently transported, generating heat instead. This uncoupling increases basal metabolic rate and thermogenesis in skeletal muscle, independent of brown adipose tissue. Sarcolipin expression is upregulated by cold exposure and thyroid hormone.
Health Claims & Evidence
Increases non-shivering thermogenesis in skeletal muscle
Protects against diet-induced obesity
Improves metabolic rate without exercise
Short-Term Effects
Unknown in humans.
Long-Term Effects
Unknown in humans. Animal data suggests metabolic protection.
Side Effects
Unknown in humans.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Sarcolipin is a newly identified regulator of muscle-based thermogenesis
Bal et al. · Journal of Cell Biology · 2012
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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