GHRP-6
Growth Hormone Releasing Peptide-6
One of the original GH secretagogues, GHRP-6 stimulates a strong pulse of growth hormone release and is notable for its significant appetite-stimulating effects.
Mechanism of Action
GHRP-6 binds to ghrelin receptors in the pituitary and hypothalamus, triggering GH release. It also stimulates ghrelin production, leading to pronounced hunger signals. Unlike Ipamorelin, it increases cortisol and prolactin to a modest degree.
Health Claims & Evidence
Potent stimulation of GH release
Increases appetite and caloric intake
Supports muscle growth and recovery
Cardioprotective effects
Short-Term Effects
Significant hunger increase within 30 minutes, improved sleep, mild GH-related effects.
Long-Term Effects
Improved body composition and recovery with consistent use. Potential desensitization with chronic use.
Side Effects
Strong appetite stimulation, water retention, increased cortisol and prolactin at higher doses, potential for desensitization.
Contraindications
Not ideal for those seeking to avoid appetite stimulation. Use with caution in diabetics.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
GHRP-6 stimulates GH secretion in humans
Bowers et al. · Endocrinology · 1990
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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