Cortagen
Cortagen (Ala-Glu-Asp-Pro)
A tetrapeptide bioregulator derived from the cerebral cortex with dual neuroprotective and cardioprotective properties. Used in anti-aging protocols targeting brain and heart tissue preservation.
Mechanism of Action
Cortagen penetrates the blood-brain barrier and acts as a gene expression regulator in neuronal and cardiac tissue. It stimulates neuronal repair and regeneration, reduces apoptosis in cortical neurons, enhances synaptic plasticity, and modulates neurotransmitter synthesis. In cardiac tissue it reduces ischemia-induced cell death, improves mitochondrial function in cardiomyocytes, and attenuates fibrotic remodeling. Its mechanism involves direct interaction with chromatin, activating genes responsible for tissue maintenance and repair.
Health Claims & Evidence
Neuroprotection and cognitive preservation in aging
Cardioprotection and reduced ischemic damage
Stimulates neuronal repair and synaptic plasticity
Extends lifespan in animal models
Reduces age-related cognitive decline
Short-Term Effects
Improved mental clarity, reduced brain fog, enhanced mood and cognitive performance.
Long-Term Effects
Potential preservation of cognitive function, reduced cardiovascular aging, neuroprotection against age-related neurodegeneration.
Side Effects
Well-tolerated in available research. No significant adverse effects documented.
Contraindications
Limited human safety data. Caution in individuals with active neurological conditions until more data is available.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Neuroprotective effects of cortical peptide bioregulators in aging
Khavinson VKh et al. · Bulletin of Experimental Biology and Medicine · 2005
Cardioprotective properties of short peptides derived from cardiac tissue
Anisimov VN et al. · Journal of Gerontology · 2008
Peptide bioregulators in the prevention of age-related pathology
Khavinson VKh, Morozov VG · Annals of the New York Academy of Sciences · 2003
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Cortagen and related peptides, and prepare an educational research summary.
Explore Research