Dihexa
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
An extremely potent nootropic peptide derived from angiotensin IV. Reported to be millions of times more potent than BDNF at promoting synaptogenesis and cognitive enhancement.
Mechanism of Action
Dihexa binds to HGF/SF and potentiates its interaction with the Met receptor, promoting synaptogenesis, neurogenesis, and dendritic spine formation. It crosses the blood-brain barrier effectively.
Health Claims & Evidence
Potent cognitive enhancement and memory improvement
Promotes synaptogenesis and neurogenesis
Potential Alzheimer's disease treatment
Short-Term Effects
Improved memory recall, enhanced problem-solving, increased mental clarity. Effects may be delayed 1–2 weeks.
Long-Term Effects
Potential for lasting cognitive improvements due to synaptogenesis. Long-term safety unknown.
Side Effects
Limited human data. Theoretical risks include excessive neuronal activation.
Contraindications
Limited human safety data. Not recommended without medical supervision.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Dihexa and cognitive enhancement in Alzheimer's models
McCoy et al. · Journal of Pharmacology and Experimental Therapeutics · 2013
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Dihexa and related peptides, and prepare an educational research summary.
Explore Research