Catestatin
Catestatin (Chromogranin A Fragment)
A chromogranin A-derived peptide that inhibits catecholamine release, reducing blood pressure and heart rate. Has anti-hypertensive and cardioprotective properties.
Mechanism of Action
Catestatin inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion from chromaffin cells, reducing sympathetic tone. It also has direct vasodilatory and cardioprotective effects.
Health Claims & Evidence
Reduces blood pressure via catecholamine inhibition
Cardioprotective effects
Anti-hypertensive properties
Short-Term Effects
Blood pressure reduction, reduced heart rate.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data. Potential hypotension.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Catestatin and catecholamine secretion
Mahata et al. · Journal of Biological Chemistry · 1997
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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