FOXO4-DRI
FOXO4-D-Retro-Inverso Peptide
A senolytic peptide that selectively eliminates senescent cells — the 'zombie cells' that accumulate with aging and drive inflammation and tissue dysfunction.
Mechanism of Action
FOXO4-DRI disrupts the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis specifically in these cells while leaving healthy cells unaffected. Senescent cell clearance reduces the SASP and its inflammatory effects.
Health Claims & Evidence
Selectively eliminates senescent cells
Reverses age-related tissue dysfunction
Reduces chronic inflammation (inflammaging)
Short-Term Effects
Potential reduction in inflammatory markers. Effects may be subtle initially.
Long-Term Effects
Theoretical reduction in age-related tissue dysfunction with repeated senolytic cycles.
Side Effects
Limited human data. Theoretical risks include excessive apoptosis in borderline cells.
Contraindications
Limited human safety data. Not recommended without medical supervision. Avoid with active cancer.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
FOXO4-DRI clears senescent cells and extends healthspan
Baar et al. · Cell · 2017
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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