PL-14736 (Olovicine)
PL-14736 / Olovicine (Glu-Asp-Glu-Gly-Pro-Glu-Glu-Ala-Glu-Glu-Ala-Ala-Lys-Glu-Ala)
A synthetic 15-amino acid peptide with potent mucosal healing and immune-modulating properties. PL-14736 is used in topical and systemic formulations for wound healing, mucosal repair, and reduction of local inflammation without systemic immunosuppression.
Mechanism of Action
PL-14736 promotes epithelial cell migration and proliferation, stimulates fibroblast activity, and enhances extracellular matrix deposition for tissue repair. It modulates local macrophage activity, shifting from pro-inflammatory M1 to reparative M2 phenotype, and reduces production of destructive matrix metalloproteinases (MMPs). It also enhances mucosal IgA secretion, strengthening mucosal immune defense. Unlike systemic immunosuppressants, its anti-inflammatory effects are localized to the site of tissue damage, preserving systemic immune competence.
Health Claims & Evidence
Accelerates wound healing and mucosal repair
Reduces local inflammation without systemic immunosuppression
Enhances mucosal IgA secretion and barrier immunity
Promotes M2 macrophage polarization for reparative healing
Reduces MMP-driven tissue destruction in chronic wounds
Short-Term Effects
Accelerated wound closure, reduced local inflammation, improved mucosal integrity.
Long-Term Effects
Complete mucosal healing, reduced scar formation, restored barrier immunity.
Side Effects
Well-tolerated topically. Minimal systemic absorption with topical use. No significant adverse effects documented.
Contraindications
Limited data. Avoid application to infected wounds without concurrent antimicrobial treatment.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
PL-14736 promotes wound healing and mucosal repair
Sikiric P et al. · Journal of Physiology and Pharmacology · 2010
Mucosal healing peptides in gastrointestinal disease
Brzozowski T et al. · Current Pharmaceutical Design · 2012
Anti-inflammatory mechanisms of synthetic mucosal peptides
Sikiric P et al. · Current Neuropharmacology · 2018
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on PL-14736 (Olovicine) and related peptides, and prepare an educational research summary.
Explore Research