GLP-2
Glucagon-Like Peptide-2 (GLP-2)
A gut hormone that promotes intestinal growth, repair, and nutrient absorption. Teduglutide (synthetic GLP-2) is FDA-approved for short bowel syndrome.
Mechanism of Action
GLP-2 binds to GLP-2 receptors on intestinal epithelial cells, stimulating crypt cell proliferation, reducing apoptosis, and increasing intestinal surface area. It also reduces gut permeability and inflammation.
Health Claims & Evidence
Promotes intestinal growth and repair
Reduces intestinal permeability
Supports nutrient absorption
Short-Term Effects
Improved intestinal function and nutrient absorption.
Long-Term Effects
Sustained intestinal adaptation and reduced parenteral nutrition dependence.
Side Effects
Abdominal pain, nausea, injection site reactions. Potential for intestinal polyp growth.
Contraindications
Active GI malignancy. Monitor for colorectal polyps.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Teduglutide in short bowel syndrome
Jeppesen et al. · New England Journal of Medicine · 2012
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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