Osteocalcin
Osteocalcin (OCN)
A bone-derived hormone with systemic metabolic effects. Promotes insulin secretion, testosterone production, muscle function, and cognitive performance.
Mechanism of Action
Osteocalcin binds to GPRC6A receptors in multiple tissues: pancreas (stimulating insulin), testes (stimulating testosterone), muscle (promoting energy utilization), and brain (promoting memory).
Health Claims & Evidence
Improves insulin sensitivity and glucose metabolism
Stimulates testosterone production
Enhances cognitive function and memory
Improves exercise performance
Short-Term Effects
Improved metabolic markers, potential testosterone elevation.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Osteocalcin and metabolic regulation
Karsenty et al. · Cell · 2007
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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