Glucagon
Glucagon (Pancreatic Alpha-Cell Hormone)
A pancreatic hormone that raises blood glucose by stimulating glycogenolysis and gluconeogenesis. Used clinically for severe hypoglycemia treatment.
Mechanism of Action
Glucagon binds to glucagon receptors in the liver, activating cAMP pathways that stimulate glycogen breakdown and glucose synthesis. It also has lipolytic effects and stimulates GH release.
Health Claims & Evidence
Rapidly raises blood glucose in hypoglycemia
Promotes fat breakdown (lipolysis)
Stimulates GH release
Short-Term Effects
Rapid blood glucose elevation within 10–15 minutes.
Long-Term Effects
Emergency use only.
Side Effects
Nausea, vomiting, headache.
Contraindications
Pheochromocytoma, insulinoma.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Glucagon in hypoglycemia management
Cryer et al. · Diabetes Care · 2003
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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