FGL Peptide
Fibronectin-derived NCAM-binding Peptide (FGL)
A 15-amino acid peptide derived from the fibronectin type III homology domain of NCAM (neural cell adhesion molecule) that enhances synaptic plasticity, improves memory, and provides neuroprotection in aging and neurodegenerative models.
Mechanism of Action
FGL binds to the FGFR1 receptor and activates downstream MAPK/ERK and PI3K/Akt signaling, promoting synaptic strengthening, BDNF expression, and neuronal survival. It enhances long-term potentiation (LTP) in the hippocampus and reduces neuroinflammation.
Health Claims & Evidence
Enhances spatial memory and learning in aging models
Neuroprotective in Alzheimer's disease models
Promotes synaptic plasticity via LTP enhancement
Short-Term Effects
Possible acute cognitive enhancement based on animal data.
Long-Term Effects
Unknown in humans. Animal data suggests sustained neuroprotection.
Side Effects
Unknown in humans. Well-tolerated in animal studies and Phase I trials.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
FGL peptide and cognitive function in aging
Secher et al. · Journal of Neuroscience · 2006
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on FGL Peptide and related peptides, and prepare an educational research summary.
Explore Research