MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondria-derived peptide that acts as a metabolic regulator. Improves insulin sensitivity, promotes fat oxidation, and enhances exercise capacity.
Mechanism of Action
MOTS-c is encoded in mitochondrial DNA and translocates to the nucleus under metabolic stress. It activates AMPK, regulates the folate cycle, and promotes glucose uptake in muscle tissue, mimicking the metabolic benefits of exercise.
Health Claims & Evidence
Improves insulin sensitivity and glucose metabolism
Promotes fat oxidation and weight management
Enhances exercise performance and endurance
Longevity and anti-aging effects
Short-Term Effects
Improved energy levels, enhanced exercise performance, better glucose control.
Long-Term Effects
Potential for sustained metabolic improvements and longevity benefits.
Side Effects
Limited human data. Generally well-tolerated in early studies.
Contraindications
Limited human safety data. Use with caution without medical supervision.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
MOTS-c is a mitochondrial-encoded regulator of metabolism
Lee et al. · Cell Metabolism · 2015
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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