Irisin
Irisin (FNDC5 Cleavage Product)
An exercise-induced hormone that mediates many of the beneficial effects of exercise. Promotes fat browning, bone formation, and neuroprotection.
Mechanism of Action
Irisin is cleaved from FNDC5 during exercise and binds to integrin receptors. It promotes white adipose tissue browning (increasing thermogenesis), stimulates bone formation, and has neuroprotective effects in the brain.
Health Claims & Evidence
Promotes fat browning and thermogenesis
Supports bone formation and density
Neuroprotective and cognitive benefits
Short-Term Effects
Potential metabolic improvements, enhanced fat burning.
Long-Term Effects
Theoretical bone and cognitive benefits with sustained use.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Irisin mediates effects of exercise on metabolism
Boström et al. · Nature · 2012
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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