GHK-Cu
Copper Peptide GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper)
A naturally occurring copper complex found in human plasma, saliva, and urine. Renowned for its potent skin regeneration, anti-aging, and wound-healing properties.
Mechanism of Action
GHK-Cu stimulates collagen, elastin, and glycosaminoglycan synthesis. It activates antioxidant enzymes, promotes angiogenesis, and modulates gene expression — upregulating over 30 genes involved in tissue repair and downregulating genes associated with inflammation and cancer progression.
Health Claims & Evidence
Stimulates collagen and elastin production
Reduces fine lines and wrinkles
Promotes wound healing and skin repair
Stimulates hair follicle growth
Antioxidant and anti-inflammatory effects
Short-Term Effects
Improved skin texture and hydration within weeks. Reduced redness and irritation. Accelerated wound closure.
Long-Term Effects
Significant improvements in skin density, elasticity, and reduction in fine lines with consistent use over months.
Side Effects
Topical: mild irritation in sensitive individuals. Injectable: generally well-tolerated. Copper toxicity is theoretical at normal doses.
Contraindications
Avoid excessive doses due to copper accumulation risk. Not recommended during pregnancy without medical supervision.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
GHK-Cu and skin regeneration
Pickart et al. · Journal of Aging Research · 2015
Copper peptides and hair growth
Uno et al. · Journal of Investigative Dermatology · 2007
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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