Metabolic & Weight Management

NPY Y2 Agonist

Neuropeptide Y Y2 Receptor Agonist Peptide

Selective Y2 receptor agonist peptides that reduce appetite and promote bone formation. Y2 receptor activation has distinct effects from full NPY.

AppetiteBoneY2 ReceptorNPYWeight Loss

Quick Reference

Category
Metabolic & Weight Management
Research Claims
3 reviewed
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Mechanism of Action

Y2 receptor agonists selectively activate NPY Y2 receptors, reducing appetite via hypothalamic mechanisms and promoting bone formation via peripheral Y2 receptors on osteoblasts.

Health Claims & Evidence

Reduces appetite via Y2 receptor activation

ModerateY2-mediated appetite suppression documented in animal studies

Promotes bone formation

Moderateperipheral Y2 receptor activation promotes osteoblast activity

Potential obesity treatment

Preliminaryselective Y2 agonism avoids appetite-stimulating Y1/Y5 effects

Short-Term Effects

Appetite suppression, potential bone formation.

Long-Term Effects

Research use primarily.

Side Effects

Limited human data.

Contraindications

Limited human safety data.

This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.

Research Papers

NPY Y2 receptor and appetite regulation

Batterham et al. · Nature · 2002

Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.

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