Nesfatin-1
Nesfatin-1 (NUCB2 Fragment)
A recently discovered satiety peptide derived from nucleobindin-2. Reduces appetite and food intake via hypothalamic mechanisms independent of leptin.
Mechanism of Action
Nesfatin-1 binds to an unidentified receptor in the hypothalamus, activating melanocortin pathways to reduce appetite. It works independently of leptin and may be effective in leptin-resistant obesity.
Health Claims & Evidence
Reduces appetite and food intake
Potential treatment for leptin-resistant obesity
Modulates stress and anxiety
Short-Term Effects
Appetite suppression, potential stress modulation.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Nesfatin-1 and appetite regulation
Oh-I et al. · Nature · 2006
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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