Adrenomedullin
Adrenomedullin (ADM)
A multifunctional peptide with potent vasodilatory, anti-inflammatory, and cardioprotective properties. Elevated in sepsis and heart failure as a compensatory response.
Mechanism of Action
Adrenomedullin binds to CLR/RAMP2 receptors, activating cAMP pathways that produce vasodilation, reduce inflammation, and protect against ischemic injury.
Health Claims & Evidence
Potent vasodilation and blood pressure reduction
Anti-inflammatory and cardioprotective effects
Potential sepsis treatment
Short-Term Effects
Rapid vasodilation, anti-inflammatory effects.
Long-Term Effects
Research use primarily.
Side Effects
Hypotension, tachycardia.
Contraindications
Not for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Adrenomedullin: a novel hypotensive peptide
Kitamura et al. · Biochemical and Biophysical Research Communications · 1993
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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